Depression: Neurotic or psychotic depressive states of diverse psychopathology and varying degree, including depression associated with organic diseases, endogenous and reactive depression, involutional melancholia, senile depressions, the depressive phase of manic-depressive psychosis and certain cases of depression for which a psychiatric basis has been established (i.e., schizophrenia, alcoholism, mental deficiency). In many cases, imipramine may be used in place of electroconvulsive therapy, or may be employed as a supplement to ECT to prevent recurrent attacks.
Persistent functional nocturnal enuresis: Also employed in children to treat persistent functional enuresis when organic causes have been excluded.